ANESTHETIC PROPERTIES OF PROPOFOL AND KETOFOL (KETAMINE WITH PROPOFOL): A COMPARATIVE STUDY

Abstract

Background: Surgical procedures require a safe anesthesia and safe anesthetic agents for this purpose use of small dose of sedative agent or any other anesthetic agent in order to reduce the dose requirement as well as adverse effects of the main inducing agent.  Therefore, this study was carried out using ketamine with propofol (KETOFOL) to compare the hemodynamic stability (Heart rate and Mean arterial pressure) and induction doses.

Methods: Fifty patients of age 18 to 60 years of ASA II and I scheduled for elective surgery to be performed under general anaesthesia were randomly selected and divided into two groups. Patient in Group-P received 50 mg propofol and Group-K received 50 mg (25mg ketamine with 25 mg propofol) intravenously bolus slowly and then 10 mg in every 10 seconds until the loss of eyelash reflex and verbal response. The hemodynamic response was noted at different given time. Chi square test and student’s t test were used for analysis.

Results: The study showed that the hemodynamic (heart rate and mean arterial pressure) was maintained and decrease in dose requirement for propofol for induction in (ketamine with propofol Ketofol group whereas there was significant decrease in hemodynamic (heart rate and mean arterial pressure) in Propofol group.

Conclusions: Our study concluded that fluctuations in heart rate and mean arterial pressure from baseline were more in propofol group compared to ketofol (ketamine with propofol) group. Therefore, Ketofol achieved better hemodynamic stability over propofol alone and also induction dose of propofol was reduced.