HISTOMORPHOLOGICAL PATTERNS OF VARIOUS KIDNEY LESIONS IN NEPHRECTOMY SPECIMENS: A FIVE YEARS EXPERIENCE IN A TERTIARY CARE HOSPITAL

Abstract

Background: A variety of non-neoplastic diseases and both benign and malignant neoplasms occur in the kidney. Radiological studies like ultrasound, CT and MRI are useful to provide a preoperative diagnosis, but histopathological study still remains the gold standard for definite diagnosis. This study aimed to explore the histomorphological patterns of various kidney lesions in nephrectomy specimens.

Methods: This was a retrospective study conducted in the department of Pathology at College of Medical Sciences, Bharatpur, Chitwan from the period of 1st August 2017 to 31st July 2022. 57 samples of nephrectomy specimens were received during the study period of five years and were included in the study.

Results: Maximum number of patients undergoing nephrectomy were in the age group of 40 to 49 years. Non neoplastic lesions constituted 87.72% of the nephrectomy specimens while the remaining were neoplastic cases. Chronic pyelonephritis was the commonest non neoplastic lesion. The commonest neoplastic lesion was renal cell carcinoma followed by transitional cell carcinoma and squamous cell carcinoma.

Conclusions: Chronic pyelonephritis is a preventable cause of nephrectomy which could be avoided with early diagnosis and no operative management. The  commonest malignant neoplasm was renal cell carcinoma.